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Notícias Internacionais / 28/07/2021

HEALTH TECHNOLOGY

Researchers Find Protein That Stops Cancer Spreading

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Researchers Find Protein That Stops Cancer Spreading

Fonte Sciense Daily

Researchers at Johns Hopkins University in the United States have identified a specialized protein that can help prevent tumor cells entering the bloodstream and spreading to other parts of the body.

The finding is promising for dealing with metastasis, in addition to the original tumor, which is a major cause of mortality.

"We found that this protein, TRPM7, detects the pressure of fluid flowing in the circulation and prevents cells spreading through the vascular system," said Dr. Kaustav Bera of Johns Hopkins University.

trip blocked

The findings help shed light on a little-known part of metastasis, called intravasation, when cancer cells that have separated a primary tumor enter the circulation to travel to other parts of the body and establish colonies.

The researchers further demonstrated that artificially increasing the expression of TRPM7 in tumor cells can help stop intravasation – and, ultimately, metastasis.

The protein detects fluid flow in the circulatory system and instructs the cell to reverse direction, thereby inhibiting intravasation.

“The process is similar to what happens when you touch a hot kettle, feel it's hot and remove your hand,” compared team member Konstantinos Konstantopoulos.

new therapies

The team also analyzed data patients with osteosarcoma, breast, gastric and liver cancer who expressed high levels of TRPM7.

The data showed that those with high levels of TRPM7 were more likely to live longer than those with lower levels of the protein.

The team says they are hopeful that these findings could lead to new cancer therapies.

"We need further development before taking this into the clinical setting, but we believe we have provided, for the first time, a definitive picture of TRPM7's role at a crucial stage in tumor metastasis," concluded Konstantopoulos.


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